【English alias】C.I. 75620; C.I. Natural Brown 1; Fisetin; 3,3,4,7-Tetrahydroxyflavone; 2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-4H- chromen-4-one
【Molecular formula】 C15H10O6
【Molecular weight】 286.23
Fisetin is a flavonoid compound, insoluble in water, carbon tetrachloride and petroleum ether, and easily soluble in acetone, acetic acid and other solvents. It is widely found in strawberries, apples, onions, cucumbers and other fruits and vegetables,cheap and easy to obtain, with a wide range of pharmacological activities, such as anti-inflammatory, antioxidant, anticoagulant, antithrombotic, antispasmodic, treatment of diabetic kidney damage and so on. In recent years, studies have found that fisetin can exert anti-tumor effects by inhibiting tumor cell proliferation and signal transduction pathways, inducing tumor cell apoptosis, etc., so it has received increasing attention.
However, this component has shortcomings such as insoluble in water and low bioavailability, which limit its further development and clinical application.
At present, the research on fisetin mainly focuses on pharmacological activity, mechanism of action, extraction process, etc., and there are few reports on related formulations. In recent years, researchers have tried to improve its solubility, bioavailability and anti-tumor effect by preparing fisetin liposomes and nanomicelles.
Improve its solubility and bioavailability, and the anti-tumor activity experiment in tumor-bearing mice found that compared with the API, low-dose liposomes can significantly increase the anti-tumor effect; preparation of fisetin micelles can increase its solubility and antitumor effect.
Although the above-mentioned nanoparticle preparations, as a new mode of administration, have achieved certain results in improving drug solubility and bioavailability, such preparations have problems such as complex process, high cost, long time consumption, and poor stability.
In order to ensure the quality of the products, XIAN YUHUI BIOTECHNOLOGY CO., Ltd has established a high-level quality inspection center, equipped with a team of high-quality scientific research personnel, and formed a strict quality control system.